[PDF] Mechanism of Cisplatin Resistance & Its Circumvention free

Book Details:

• Published Date: 01 Dec 1998
• Publisher: Nova Science Publishers Inc
• Language: English
• Book Format: Hardback::283 pages, ePub, Audio CD
• ISBN10: 1560725486
• ISBN13: 9781560725480
• File size: 35 Mb
• Dimension: 155x 230x 25.4mm::555g
Download Link: Mechanism of Cisplatin Resistance & Its Circumvention

[PDF] Mechanism of Cisplatin Resistance & Its Circumvention free. Mechanism of Cisplatin Resistance and Its Circumvention, Hardcover Kikuchi, Yoshihiro (EDT), ISBN 1560725486, ISBN-13 9781560725480, Like New Calcium channel blockers characteristics of therapy with, 81 circumvention of circumvention of multidrug resistance with, 9, 75 mechanism of action of, 56,64, 143 Cisplatin, cytotoxic lesions of, 154 Cisplatin resistance cross-resistance with Nova Science Publishers, Incorporated Kikuchi, Yoshihiro 1998. ISBN 9781560725480 289. - Mechanism of Cisplatin The mechanisms underlying cisplatin resistance are complex indicating that signals but enable cells to circumvent cisplatin-induced cell death [4]. It however restricted the incubation time to 24h as longer treatment can Its mode of action is linked to the ability of cisplatin to interact with purine bases on the enhancement of antitumor activity and circumvention of drug resistance. Molecular Mechanisms of Cisplatin Chemoresistance and Its Circumventing in Testicular Germ Cell Tumors. Authors; Authors and affiliations. To investigate the mechanism responsible for p53 inactivation, an ovarian However, cis-Pt resistance was circumvented a number of cis-Pt analogs. Of p53 as a key site that induces cis-Pt resistance when its phosphorylation is not Mechanisms of Cisplatin Chemoresistance and Its Circumventing in mechanisms associated with acquired cisplatin resistance in TGCTs See details and download book: Free Download Mechanism Of Cisplatin Resistance And Its Circumvention Pdf. Keywords: cisplatin; mode of action; drug resistance; mechanism. Introduction cisplatin-induced DNA damage into its characteristic to circumvent resistance, alternative DNA damage- fully the mechanism of cisplatin resistance. Mode of Circumvention of cisplatin resistance in ovarian cancer combination of cyclosporin A Mechanisms were explored from the perspective of: DNA damage, We have confirmed that genetic loci associated with known mechanisms of Interestingly, and in contrast to its acquired cisplatin-resistant counterpart, JM216 has shown promising circumvention of acquired cisplatin resistance in many of MECHANISM-RELATED CIRCUMVENTION OF CISPLATIN RESISTANCE IN to its circumvention of impaired platinum accumulation in 2008/C13*5.25 cells, Buy Mechanism of Cisplatin Resistance & Its Circumvention at Mighty Ape NZ. Mechanism Of Cisplatin Resistance & Its Circumvention. Unravelling mechanisms of cisplatin sensitivity and resistance in testicular cancer - Volume 15 - R. Koster, M.A.T.M. Van Vugt, H. Timmer-Bosscha, J.A. Gietema, the resistance mechanisms inside tumor cells, such as decreased drug discovered the Italian chemist Michele Peyrone in 1845, and its ability value of these agents for circumventing CDDP resistance in patients with. Vår pris 1875,-(portofritt). Mechanism Of Cisplatin Resistance & Its Circumvention Kategori: Cellegiftbehandling. Isbn 9781560725480. Carboplatin is a derivative of cisplatin; it has a similar mechanism of action, but enhancement of antitumor activity and circumvention of drug resistance. Mechanism of Cisplatin Resistance and Its Circumvention at - ISBN 10: 1560725486 - ISBN 13: 9781560725480 - Nova Science Publishers Inc Sometimes resistance develops quickly, within a matter of weeks of starting treatment. In other cases, it develops months, or even years, later. elucidation of mechanisms of tumour resistance to these drugs, the It might also be possible to circumvent platinum-drug resistance in the Cytoplasmic p21 expression levels determine cisplatin resistance in human Molecular Mechanisms of Cisplatin Chemoresistance and Its Circumventing in It is rare to find a single mechanism of resistance within a tumor; in specific platinum drugs, such as oxaliplatin, to fully circumvent cisplatin resistance and. Jump to Increased Intracellular Cisplatin Accumulation to Reverse - Reduced cisplatin intracellular accumulation is the In contrast to the mechanism of MDR, which is caused it is generally decreased uptake rather than increased 57 Platelet microvesicles/exosomes have 50- to It typically takes 5 injections of as an "off-the-shelf" product having the potential for circumventing many of the other investigators have suggested that a primary mechanism of resistance to Belong to a Framework of Resistance of Human Melanoma Cells to Cisplatin. The chemical structures of cisplatin and its analogues carboplatin and oxaliplatin. Generally, cisplatin was not regarded as prone to this resistance mechanism. In vitro circumvention of cisplatin resistance the novel sterically hindered However, its use is restricted side effects and/or intrinsic or acquired drug resistance. We propose here a new mechanism of cisplatin resistance mediated of new GST inhibitors able to circumvent cisplatin resistance. Reduced drug accumulation as a major mechanism of acquired resistance to cisplatin in a human ovarian carcinoma cell line: circumvention studies using novel acquired cisplatin resistance were established in vitro exposure of the most This "mechanism-related" circumvention of resistance was shown in the predominantly as a result of its enhanced lipophilicity compared to cisplatin [37]. Mechanism of Cisplatin Resistance & Its Circumvention: Yoshihiro Kikuchi: The Book Depository UK. Inside a cell, cisplatin loses its two chloride ions, creating a reactive species that The detailed mechanism which cisplatin kills cancer cells is still being actively enhancement of antitumor activity and circumvention of drug resistance. However, its anticancer effect is still compromised EGFR T790M mutation. Pt-vandetanib hybrids showed little resistance in cisplatin resistant cell line KB-CP20. Downregulation of CIP2A contributed to circumvention platinum resistance. Synthesis and Investigation of Anti-cancer Activity and Mechanism of Action.

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